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KMID : 0385520220350040143
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Analytical Science & Technology
2022 Volume.35 No. 4 p.143 ~ p.152
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A Review: Synthesis and characterization of metals complexes with paracetamol drug
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AL-Ayash Salam R.
AL-Noor Taghreed H.
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Abstract
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In this review, previous studies on the synthesis and characterization of the metal Complexes with paracetamol by elemental analysis, thermal analysis, (IR, NMR and UV-Vis (spectroscopy and conductivity. In reviewing these studies, the authors found that paracetamol can be coordinated through the pair of electrons on the hydroxyl O-atom, carbonyl O-atom, and N-atom of the amide group. If the paracetamol was a monodentate ligand, it will be coordinated by one of the following atoms O-hydroxyl, O-carbonyl or N-amide. But if the paracetamol was bidentate, it is coordinated by atoms (O-carbonyl and N-amide), (O-hydroxyl and N-amide) or (O-carbonyl and O-hydroxyl). The authors also found that free paracetamol and its complexes have antimicrobial activity.
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KEYWORD
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complex, donor atom, paracetamol, analytical and spectral studies
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